With What is Semaglutide Being Compounded?

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist medication. It is FDA-approved under the brand names Ozempic and Wegovy for treating type 2 diabetes and obesity, respectively.

However, there are concerns about compounded semaglutide. The FDA has received reports of adverse events after people used compounded semaglutide [3].

Here’s why:

  • Uncertain ingredients: Semaglutide itself is not commercially available to compounding pharmacies from the original manufacturer. This means that compounded versions may contain different ingredients, including salt forms of semaglutide (like semaglutide sodium or semaglutide acetate) that have not been tested for safety and effectiveness [1, 2, 3].
  • Lack of FDA oversight: The FDA does not review compounded versions of drugs like semaglutide for safety, effectiveness, or quality [1]. This means there is no guarantee that compounded semaglutide is pure, potent, or sterile.

If you are considering semaglutide to treat type 2 diabetes or obesity, it is best to talk to your doctor about getting an FDA-approved prescription for Ozempic or Wegovy. These medications have been rigorously tested and are known to be safe and effective.